Acute promyelocytic leukemia, from clinic to molecular biology.
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Acute promyelocytic leukemia, from clinic to molecular biology. by S.J Chen

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Published .
Written in English


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Open LibraryOL19593716M

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T1 - The molecular biology of acute promyelocytic leukemia. AU - Slack, J. L. AU - Gallagher, R. E. PY - Y1 - N2 - The preceding two years have witnessed an explosion in the accumulation of Cited by: Acute promyelocytic leukemia (APML, APL) is a subtype of acute myeloid leukemia (AML), a cancer of the white blood cells. In APL, there is an abnormal accumulation of immature granulocytes called Specialty: Hematology and oncology. Abstract. In this chapter, our goal is to review and summarize current knowledge of the molecular biology of acute promyelocytic leukemia (APL). The cure of up to 75% of patients with APL [1, 2] represents a Cited by: The molecular biology of acute promyelocytic leukemia. Slack JL(1), Gallagher RE. Author information: (1)Department of Medicine Roswell, Park Cancer Institute, Buffalo, New York , USA. The Cited by:

  Acute promyelocytic leukemia is a form of acute myeloid leukemia, a cancer of the blood-forming tissue (bone marrow).In normal bone marrow, hematopoietic stem cells produce red blood . Management of patients with acute myeloid leukemia relies on genetic tests that inform diagnosis and prognosis, predict response to therapy, and measure minimal residual disease. The value of genetics Cited by: However, observations of the striking efficacy of all-trans-retinoic acid (tretinoin) in the treatment of patients with acute promyelocytic leukemia, followed closely by the discovery of a Cited by: This review highlights new findings that have deepened our understanding of the mechanisms of leukemogenesis, therapy and resistance in acute promyelocytic leukemia (APL). Promyelocytic Cited by: 3.

Alcalay M, Zangrilli D, Pandolfi PP, Longo L, Mencarelli A, Giacomucci A, Rocchi M, Biondi A, Rambaldi A, Lo Coco F, Diverio D, Donti E, Grignani F, Pelicci PG (): Translocation breakpoint of acute Cited by: 1. In this chapter, our goal is to review and summarize current knowledge of the molecular biology of acute promyelocytic leukemia (APL). The cure of up to 75% of patients with APL [1,2] represents a. Acute promyelocytic leukemia (APL) represents one of the best paradigms of successful targeted therapy by providing the first example of chemotherapy-free cure of acute leukemia. APL is in fact one of the Cited by: Among hematologic malignancies, APL is one of the best-characterized genetic-clinical entities. In fact, (1) a unique molecular lesion (the PML/RARα fusion gene) segregates with a single phenotype (hyper Cited by: